Studies show that pediatric tumors may be genetic

A type of pediatric brain tumor that may be considered a known genetic pathway for low-grade gliomas is difficult to cure for medical care, according to a new study published in the journal Neuropunch published Thursday.

Dr. Fausto Rodriguez, Assistant Professor of Pathology and Oncology at Johns Hopkins University, and colleagues report that the mammalian rapamycin target protein (mTOR) pathway is highly active in low-grade glioma in children , And blocking the use of a pathway for this experiment may reduce the growth of these tumors.

We think the function of mTOR can be used as an Achilles heel. Drives the growth of cancer cells, but when mTOR is the co-author Dr. Eric Rabe, a co-author of the study of tumor-suppression-disintegration, an assistant professor at the Johns Hopkins University Kimmel Cancer Center, Pediatrics, Oncology, and Pathology. Although these tumors are considered to be of low grade and are not particularly positive, many patients suffer from severe, life-changing symptoms, so we desperately need better treatment.

He added that the impact of brain tumours is the primary cause of cancer-related deaths in more than 4,000 American children each year and not yet 18 years of age. Low-grade gliomas are the most common type of tumor found in the juveniles of the central nervous system and current treatment conditions, including surgery and chemotherapy - a toxic process that often carries serious side effects and explains the team.

In addition, many low-grade gliomas are located in areas where they can be easily removed, such as the optic nerve. Removing tumors can lead to loss of vision, and even loss of vision. For example, Loeb also reported that some patients had learning disabilities or after treatment or after tumor resection. As part of their research, Rodriguez and his colleagues organized a sample analysis from 177 pediatric low-grade glioma patients at Johns Hopkins University and other medical facilities. They also used an experiment called MK8669 (ridaforolimus) to block mTOR in a pair of low-grade glioma cell lines in children.


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